Flossie is a diminutive of Florence. Florence originates in Latin language and means "thriving". It is taken from the name of the capital city of Tuscany, Italy. It is also the name of several places in the United States. Formerly, it was used as both feminine and masculine given names, today it is more popular for girls. The famous bearer was Florence Nightingale, a British nurse in the Crimean War. In the United States, the usage of Florence has been declining.